Principal Scientist, Gene Correction

Who We Are:

We are an integrated genetic medicines company with a next-generation lipid nanoparticle platform developing targeted medicines for patients with orphan respiratory diseases. Our treatments address the underlying genetic cause in underserved populations and have the potential to tremendously impact the quality and length of patients’ lives.

At ReCode, we bring a unique blend of rigor, creativity, and curiosity to our high-hurdle mission to deliver the future of genetic medicines. Our team is uniquely positioned to tackle this challenge, given our extensive experience in RNA delivery technologies, gene editing, lipid nanoparticle delivery and drug development.

Summary of Position:

Recode is developing non-viral gene editing systems using proprietary SORT LNP delivery platform. We are seeking a Principal Scientist to be part of research and development gene editing team to build the internal gene editing platform for translational research to develop innovative new therapeutics for rare diseases. This individual will also collaborate with cross functional teams that combine Biology, and Drug Development and Safety expertise to advance innovative molecules to the clinic. The candidate must have a strong molecular biologist technical expertise, in-depth conceptual and practical understanding of gene editing therapeutics engineering strategies, and an understanding of key challenges related to non-viral delivery. This role will provide a challenging and very rewarding opportunity for career development with an innovative gene engineering attitude. A previous experience in cellular therapy, industry or academic, is preferred.

Responsibilities:

• Design and evaluate gene editing constructs in mammalian cells
• Establish and perform molecular assays to determine on target gene editing efficacy
• Onboarding and assess next generation sequencing based assays to determine genome wide off target mutagenesis
• Design experiments, organize and analyze results and communicate progress to the group.
• Develop and implement platform methods for high through DNA construction, preparation, QC, and screening.
• Responsible for establishing operating and managing resource and providing scientific guidance to research associates and scientists
• Evaluate and prioritize non-viral engineering strategies and deliver complete data packages to allow for timely Go/No Go decisions.
• Collaborate with SME, inside and outside the team, to evaluate the functional impact of proposed non-viral engineering strategies on CAR and TCR cell products.
• Interface with the cell therapy development organization to evaluate at-scale feasibility/performances of research-scale proof-of-concepts.
• Work with other team members and team leaders to modify SOPs (for single and multiplexed gene editing applications) and to implement novel non-viral strategies in ongoing programs.
• Responsible for memos, technical reports, and relevant sessions of IND filing.
• Understand the context, impact, and timely communication of data.
• Ability to multitask, independently organize time, and plan specifics of work.
• Excellent communication and facilitation skills demonstrated in a team environment.
• Detail-oriented with the ability to identify and implement creative solutions.
• Willingness to think outside the box, be creative and ability to work in a very fast paced, ever changing environment.
• Experience in the following areas is plus: in vitro technologies including but not limited to MSD, multi-parameter flow cytometry for phenotypic characterization of T cells, T cell activation assays, T cell proliferation analysis, imaging. innovation, collaboration, and communication.

Qualifications:

• PhD in Molecular Biology or related area with a minimum of 7 years of biologics industry experience in vector engineering.
• Experienced in vector engineering in both viral and non-viral systems.
• Strong knowledge and skills in gene editing technologies, ie CRISPR-Cas9, targeted integration, knock-out or knock-in, inducible system, etc..
• Deep understanding of gene regulation mechanisms at genetic, epigenetic, transcription, and translation levels.
• Should have an in-depth knowledge on DNA repair and DNA sensing pathways in human cells.
• Experienced in constructing and modifying vector backbone and regulatory elements.
• Excellent project leadership skills in driving for results and innovation; ability to execute within a matrixed organization.
• Ability to articulate scientific data and strategic messages to all partners and team member
• Clear record of skills in writing, communication, and formulation of scientific arguments
• Strong attention to detail with the ability to multi-task and handle multiple responsibilities simultaneously.
• Previous experience in base editors, preferred
• Previous experience in translational gene editing research, preferred

ReCode Therapeutics (www.recodetx.com) offers a competitive compensation/benefits package with a friendly, collaborative culture that values employee engagement and ongoing career development.

ReCode Therapeutics is an Equal Opportunity Employer.